Category Archives: Vitamins

Big Pharma’s Battle against Vitamins and Homeopathic Medicine – Center for Research on Globalization

It is difficult to get a man to understand something when his salary depends on his not understanding it. (Upton Sinclair)

(OMNS Sept 1, 2017) Now theres yet another article cautioning readers to not take vitamins because they may somehow increase the risk for lung cancer. [1,2]

Attacks pushing drug treatment, in preference to less expensive and more effective treatment with vitamins and other essential nutrients, have become quite common in recent years. Orthomolecular medicine has adapted to such assaults. The field now looks forward to these spurious attacks because they provide a level of comic relief from the tensions of serious orthomolecular research.

The gist of the article is the following: Epidemiologists at two American cancer research institutes (Mayo Clinic and Ohio State University) and the National Taiwan University studied 77,000 men between the ages of 50-76. The research institutes found evidence to suggest that long term (10 years) high dose supplementation with 20 mg of vitamin B6 (Pyridoxine Hydrochloride) and 55 mcg of B12 (cobalamin) nutrients that are necessary for proper cellular metabolism throughout the body was linked with a 3-fold increase in risk of developing lung cancerin men who regularly smoked.

I think smoking is such a wild card that it can throw off many a study. To me, it would be like studying the effects of artificial colors in soft drinks . . . when served to people dying of thirst. (Andrew W. Saul)

What was not made clear during the rant was why vitamins B6 and B12 were chosen for lung cancer research. Indeed, Abram Hoffer, MD, PhD, has written of the great value of these nutrients, saying

vitamin B6 should be taken for the protection against arteriosclerosis, heart disease and strokes. Vitamin B6 is one of the nutrients essential in the conversion of homocysteine to the nontoxic cystathionine. Vitamin B12 (cobalamin) is used to maintain the health of all body cells by production of nucleic acid. It maintains nerve tissue sheaths, helps in blood formation and the production of genetic material DNA and RNA and affects protein and fat cells. [3]

Modern medicine places a great deal of importance on RDA vitamin intake, believing a good diet will somehow provide all the necessary nutrients to maintain good health. There is this ingrained belief that higher, optimal doses of vitamins are not necessary. Yet when it comes to treating pernicious anemia, conventional physicians will frequently use megadoses of B12 such as 100 mcg injections. 100 mcg is 40 times the RDA. They are inadvertently practicing orthomolecular medicine. Why cant they expand their minds to using mega-doses of other vitamins?

The authors of the above-mentioned article missed the fact that the most recent data (2015) from the United States National Poison Data System emphatically states that there were no deaths from vitamins, no deaths from minerals or amino acids, and no deaths from homeopathics or herbs.[4,5]

The article is misleading because it only showed an association (correlation) with an increased risk of lung cancer in smokers. It only assessed the amount of B vitamins that the study participants were consuming via dietary surveys, not actual blood levels. The article makes no mention of the source of B vitamins in the participants diet. I doubt, in the smokers, that they are coming from an over-consumption of leafy greens! And the study only evaluated current or past smokers, as there were too few never-smokers to evaluate associations. Therefore one is suspicious that the problem was smoking, not the vitamin B6 or B12 reported in the diet.

Further, the risk of previous smokers was significantly less than for current smokers, implying that smoking was the true risk factor, not vitamin intake. In fact, some previous studies have found no association, or even an inverse (protective) relationship between blood levels of vitamins B6 and B12 and lung cancer! [6,7]

Said one study:

The authors found significantly lower risk of lung cancer among men who had higher serum vitamin B6 levels. Compared with men with the lowest vitamin B6 concentration, men in the fifth quintile had about one half of the risk of lung cancer. [7]

Vitamins are not the problem. In fact, they can prevent lung cancer. The pioneering research conducted by Indu B. Chatterjee, PhD, demonstrates the importance of taking adequate doses of vitamin C and other essential nutrients.

Dr. Chatterjee was a colleague of Drs. Irwin Stone and Nobel Laureate Linus Pauling. Here is a quote from Chatterjee: I had indeed significant contact with the late Dr. Irwin Stone and Linus Pauling. In fact, Dr. Irwin Stone sent a copy of his bookThe Healing Factor: Vitamin C Against Diseasewith a handwritten inscription in red ink: In appreciation for your pioneering work on ascorbate biosynthesis, dated 13 March 1974. In an e-mail sent to me five years ago it is quite apparent that Dr. Chatterjee was a more skillful marksman and superior researcher than the epidemiologists at the two American Cancer research institutes and the National Taiwan University. He wrote:

Besides having the importance of vitamin C in our day to day nutrition, our recent work indicates that vitamin C is really a panacea for preventing cigarette smoke-related fatal diseases like emphysema, cardiovascular disease, and also lung cancer. Although cigarette smoke contains about 4000 compounds, p-benzoquinone produced from p-benzosemiqinone of cigarette smoke in the lungs of smokers appears to be a major factor for producing the diseases.

All commercial cigarettes contain substantial amounts (100-200 micrograms/cigarette smoke) of p-benzosemiquinone, which is oxidized to p-benzoquinone in the lungs of smokers and denatures proteins and DNA. From lungs, p-benzoquinone goes to blood and all organs. Because these dreadful diseases have no cure, prevention should be the target. Vitamin C is a strong antagonist of p-benzoquinone and intake of a moderately large amount of vitamin C (about 2,000 mg/day) by smokers should almost completely prevent cigarette smoke-induced diseases. In support of this, I am appending below some of our recent publications. [8-13]

Conclusion

If you want to reduce your risk of lung cancer or any type of cancer, and also of heart disease you canstop smoking. The risk goes down once you stop. And dont believe the shills. You should take adequate doses of the B vitamins, and vitamins C, D, and E. [14,15]

Notes

1. We Should Never Have Told People to Start Taking Vitamins and New Research Linking One Type to Cancer Shows Why.https://www.aol.com/article/news/2017/08/24/we-should-never-have-told-people-to-start-taking-vitamins-and-new-research-linking-one-type-to-cancer-shows-why/23178576/

2. Brasky TM, White E, Chen CL. Long-Term, Supplemental, One-Carbon Metabolism-Related Vitamin B Use in Relation to Lung Cancer Risk in the Vitamins and Lifestyle (VITAL) Cohort. J Clin Oncol. 2017 Aug 22:JCO2017727735.https://www.ncbi.nlm.nih.gov/pubmed/28829668

3. Hoffer A, Walker M, Putting It All Together: The New Orthomolecular Nutrition, Keats Publishing, Inc. 1978, p 112-114

4. Saul AW. No Deaths from Vitamins. None. Safety Confirmed by Americas Largest Database. Orthomolecular Medicine News Service, Jan 3, 2017http://orthomolecular.org/resources/omns/v13n01.shtml

5. Saul AW. No Deaths from Supplements. No Deaths from Minerals or Amino Acids. No Deaths from Homeopathics or Herbs. Orthomolecular Medicine News Service, Jan 5, 2017.http://orthomolecular.org/resources/omns/v13n02.shtml

6. Johansson M, Relton C, Ueland PM, et al. Serum B vitamin levels and risk of lung cancer. JAMA. 2010; 303:2377-2385.https://www.ncbi.nlm.nih.gov/pubmed/20551408

7. Hartman TJ, Woodson K, Stolzenberg-Solomon R, Virtamo J, Selhub J, Barrett MJ, Albanes D. Association of the B-vitamins pyridoxal 5-phosphate (B(6)), B(12), and folate with lung cancer risk in older men. Am J Epidemiol. 2001; 153:688-94.https://www.ncbi.nlm.nih.gov/pubmed/11282797

8. Das A, Dey N, Ghosh A, Das T, Chatterjee IB. NAD(P)H: quinone oxidoreductase 1 deficiency conjoint with marginal vitamin C deficiency causes cigarette smoke induced myelodysplastic syndromes. PLoS One. 2011; 6(5):e20590.https://www.ncbi.nlm.nih.gov/pubmed/21655231

9. Dey N, Chattopadhyay DJ, Chatterjee IB. Molecular mechanisms of cigarette smoke-induced proliferation of lung cells and prevention by vitamin C. J Oncol. 2011; 2011:561862.https://www.ncbi.nlm.nih.gov/pubmed/21772844

10. Ghosh A, Choudhury A, Das A, Chatterjee NS, Das T, Chowdhury R, Panda K, Banerjee R, Chatterjee IB*. Cigarette smoke induces p-benzoquinone-albumin adduct in blood serum: Implications on structure and ligand binding properties. Toxicology. 2012 Feb 26;292(2-3):78-89.https://www.ncbi.nlm.nih.gov/pubmed/22154986

11. Das A, Dey N, Ghosh A, Das S, Chattopadhyay DJ, Chatterjee IB. Molecular and cellular mechanisms of cigarette smoke-induced myocardial injury: prevention by vitamin C. PLoS One. 2012; 7(9):e44151.https://www.ncbi.nlm.nih.gov/pubmed/22970172

12. Chatterjee IB. The history of vitamin C research in India. J Biosci. 2009 ; 34:185-94.https://www.ncbi.nlm.nih.gov/pubmed/19550033

13. Banerjee S, Chattopadhyay R, Ghosh A, Koley H, Panda K, Roy S, Chattopadhyay D, Chatterjee IB. Cellular and molecular mechanisms of cigarette smoke-induced lung damage and prevention by vitamin C. J Inflamm (Lond). 2008; 5:21.https://www.ncbi.nlm.nih.gov/pubmed/19014449

14. Hoffer A, Saul AW, Orthomolecular Medicine for Everyone. Basic Health Publications, Inc., 2008. 376 pages.

15. Vitamin E Attacked Again. Of Course. Because It Workshttp://orthomolecular.org/resources/omns/v07n11.shtml

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Big Pharma’s Battle against Vitamins and Homeopathic Medicine – Center for Research on Globalization

Should You Take Vitamin B12 Before a Workout? – BarBend (blog)

If youve tried as many pre-workouts and branch chain amino acid powders as we have, theres a decent chance youve come across a sports supplement with Vitamin B12 in it.

You probably know that Vitamin B12 is only found in animal products, and you might have a feling that B-vitamins are important for energy production. So, taking a shot of B12 before a workout must help you produce energy for the workout, right?

This probably isnt the case, but there are other reasons why a B12 supplement could help a workout.

If you dont get enough Vitamin B12, symptoms start with an overall sense of weakness and can proceed to numbness or tingling in the hands or feet, memory loss, cognitive decline, and anemia. The good news is the symptoms are reversible once you restore your B12.

VitaminB12plays a role in a number of different processes in the body, including energy production, amino acid and DNA synthesis, blood cell formation, and brain and nerve cell function, says Bill Willis, PhD, a biomedical scientist and a researcher at Examine.com. Getting enough B12 may also help to minimize risk for cardiovascular disease and it can prevent certain cancers too it helps to prevent inappropriate gene expression that can lead to cell transformation and cancer.

OK, so its healthy in the longterm. But is that the only reason it could help my workouts?

If you have a deficiency, it will absolutely affect workout performance, says Trevor Kashey, PhD, a nutrition scientist and consultant with Complete Human Performance. If your normal is crappy and it brings you back to normal, youre going to feel like youve improved your performance but really youve gone from negative one to zero.

The issue is that when people hear that it helps with energy production, they take that to mean its a stimulant. Its not, it just helps with normal energy production. (Though the helps with energy tagline is great for supplement marketing.)

If you continue to take a vitamin and its helping you more and more, I dont think that means youre taking more than you need, says Kashey. It probably means you havent gotten enough.

Some people theorize that if youre an athlete, then you need more B vitamins than the average person, but Kashey points out that even if that were the case and hes not convinced it is athletes are going to be eating more calories (and therefore, almost certainly more nutrients) than the average person anyway. So this means it doesnt look like athletes need to supplement with a zillion percent of the RDI of B12.

There are some folks who feel that its smart to increase B12 intake surrounding exercise because while lifting weights increases protein synthesis, it also increases protein breakdown.

This is a reason why people take branch chain amino acid supplements, to shift the balance toward protein accumulation by boosting protein synthesis, slowing protein breakdown, or doing both.

BecauseB12cant be made in the body and is required for the synthesis of the amino acid methionine, it is often included with BCAAs under the assumption that requirements will increase under conditions of increased protein synthesis, says Willis. While this argument looks great on paper, it has yet to be established thatB12levels in those without a deficiency are ever a bottleneck for protein synthesis.

If youre wondering why you see B12 in your BCAAs, this is probably it. But the evidence isnt solid enough to definitively state that this is why you should take B12 with your pre-workout.

Probably less than you think.

The National Institute of Health recommends about 2.4 micrograms of Vitamin B12 per day for anyone over the age of 14, with slightly higher recommendations if youre pregnant (2.6mcg) or lactating (2.8mcg).

[You absorb less Vitamin B12 as you age, so its one of these 4 Nutrients You May Need More of After 50.]

Vitamin B12 is only found in animal sources. Far and away the best sources are clams (they have 84 micrograms per three-ounce serve) and liver (70 micrograms per three-ounce serve). But its also high in fish (three ounces of salmon has 4.8mcg, the same amount of tuna has 2.5mcg), eggs (six of them will provide 3.6mcg), beef (2.4mcg in three ounces) and milk (one cup has 2.4mcg).

Unless youre eating plenty of animal products, those numbers might make you think that youre not hitting your RDI as much as you should. But remember how liver was so much higher than other sources? Thats because animals store B12 in their liver, and so do humans. In fact, according to the Mayo Clinic, the human body stores several years worth of vitamin B12 in the liver, which is why low levels are so rare.

That doesnt mean you never have to think about your B12, particularly since a few different factors, like age and gastrointestinal issues, can affect how well we actually absorb the B12 we consume. But it does mean that if youre eating a varied diet, B12 intake probably doesnt need to be that high on your list of priorities.

Were not about to say that no one needs to supplement. It can be hard, inconvenient, expensive, or time-consuming to nail your RDI of every single vitamin and mineral youre meant to eat.

But there are probably micronutrients that are more important, and harder to get, than B12. Studies have found that youre far more likely to be low in B12 if youre over 60 and even then, only about 6 percent of people are deficient. Compare that with an estimated half of all Americans being deficient in Vitamin D and magnesium and it becomes clear there are other nutrients that deserve your attention.

Bozian RC, Ferguson JL, Heyssel RM, Meneely GR, Darby WJ. Evidence concerning the human requirement for vitaminB12. Use of the whole body counter for determination of absorption of vitaminB12.Am.J.Clin.Nutr.1963;12:117-29.

Fenech M. Folate (vitamin B9) and vitaminB12and their function in the maintenance of nuclear and mitochondrial genome integrity.Mutat.Res.2012;733:21-33.

Kuzminski AM, Del Giacco EJ, Allen RH, Stabler SP, Lindenbaum J. Effective treatment of cobalamin deficiency with oral cobalamin.Blood1998;92:1191-8.

Lukaski HC. Vitamin and mineral status: effects on physical performance.Nutrition2004;20:632-44.

Featured image via @crossfitunionsquare and @wodpix on Instagram.

Excerpt from:
Should You Take Vitamin B12 Before a Workout? – BarBend (blog)

Orb High-Tech Vitamins Will Change Your Beauty Sleep Forever – Us Weekly

Here at Stylish, were into just about any kind of supplement that will help boost our beauty. So when we got news of Orb, the first high-tech vitamin range of its kind, we were stoked, because not all supplements are made equal.

What makes these daily pills different than your average omega-3 dose? It all starts with the Orb exclusive time-release technology called Terra Intelligent Dosing that gradually releases nutrients throughout the day to boost absorption, and therefore the effectiveness of the vitamin you’re taking.

Brand founder Matt Hesse talked to Us about how Orb is going to change the supplement game. Essentially, the difference between a traditional vitamin and Orb is that regular vitamins last in your body for the amount of time theyre being process through your digestive tract but these high-tech daily supplements are going to turn this limitation on its head. Orb vitamins reinvent that by taking pharmaceutical technology and emerging that with natural ingredients. You get the best of the pharmaceutical world without the side effects and you get the best of the natural world but in a more effective way, said Hesse.

Orb also relies on 2-in-1 ingredient combinations delivered in a binary system: oil and beadlets. What does this mean? Well, each dose has its essential nutrients bundled in combinations, so you can take a multivitamin and fish oil in one pill. Basically, you do double duty with one supplement.

For starters the Sleep Complex takes the woes of a typical melatonin users (such as waking up after it wears off a couple hours later) and eliminates that issue allowing the sleep-inducing ingredients to be released throughout the night, during the different stages of the sleep cycles so your sleep is sustained (and more restful!). Then, in the morning it releases a dose of vitamin B12 to wake you up.

There are a number of different Orb supplements to choose from, including Mens Multi + Fish Oil, Womens Multi + Fish Oil, Heart Complex, Mental Focus + Mood, Sleep Complex, Smooth Energy Complex, and lastly a Hair, Skin, Nails + Collagen supplement. Essentially, whatever your health need, Orb has an effective solution.

ORB is available nationally online and in-store, at Amazon, GNC, and Vitamin World, and retails for $39.99 (60 capsules) and $19.95 (30 capsules).

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Orb High-Tech Vitamins Will Change Your Beauty Sleep Forever – Us Weekly

Beauty salon launches ‘revolutionary’ treatment to give you a boost – vitamins fed through a drip – Gazette Live

A brand new beauty treatment has arrived on Teesside – but theres a catch.

Cosmedics Skin Clinic is offering revolutionary beauty treatments, but you must hook up to an intravenous drip at their clinic in Middlesbrough.

IV therapy claims it targets a variety of needs through a targeted vitamin boost.

The treatment already has massive popularity across the globe, with stars such as Kim Kardashian, Kate Moss and Rihanna among its fans.

Dr Wass, who opened the Gresham Road clinic around eight weeks ago, claims the treatment can also help people recover from illness or tiredness, restoring vitamin and nutrient levels while overall cosmetic appearance is given a refresh.

Research shows that 90% of people are nutrient deficient, and 50% of those people are already taking a multivitamin. Dr Wass said.

That is the reason for us deciding to venture as IV vitamin drips are a revolution in vitamin supplements which were first invented in 1960s and have since taken the world by storm.

There are nine different types of IV drips, which clients can choose from; Wellness Protcol, Mood Support, Athlete Sport, Booster Shot Glutathione, Energizer, Age Defiance, Detox Fat Burning, Immuno Booster and Hair Tonic.

Dr Wass said: We would suggest patients start with the wellness cocktail as this contains the right mix of vitamins, minerals and antioxidants for an overall feeling of wellness and health promotion.

It is claimed the drip combats and treat the effects of factors such as dehydration, strenuous physical activity, ageing and fatigue.

Each drip can take between 45 minutes and 90 minutes to administer and start from 175 per shot.

After a consultation with a doctor, those hoping to indulge in some recovery time are fitted with a cannula and attached to a drip bag containing the chosen formula.

Only after a full assessment, do we decide which type of drip will be suitable for each client, Dr Wass said.

Our goal is to provide varying nutrients directly into your bloodstream for maximum cell absorption. This will immediately refuel your cells, restore balance & overall well-being both physically and mentally.

We are hoping to help those who live a fast-paced lifestyle by offering them a quick pick-me-up, without having to wait for results.

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Beauty salon launches ‘revolutionary’ treatment to give you a boost – vitamins fed through a drip – Gazette Live

High doses of energy-boosting vitamin B12 and B6 supplements … – The Sun

THEY are an every day supplement sold to us as a natural way to boost energy.

But over-the-counter vitamin B12 and B6 supplements may significantly increase a man’s risk of developing lung cancer.

Getty – Contributor

A new study found that men who take high doses of the energy-boosting vitamins over a long period had a two-to-four-fold increased risk of developing the disease.

And the risk if even higher if they smoke.

Vitamin B12 and B6 are both involved in keeping red blood cells – the cells that carry oxygen throughout the body – healthy and absorbing and releasing energy from foods like proteins, fats and carbs.

They are found naturally in meats, fish, cheese, eggs, milk and fortified cereals but millions of people in the UK choose to take supplements that can be boughtin pharmacies and supermarkets.

The NHS recommends men eat 1.4 milligrams of vitamin B6 a day and 1.5 micrograms of vitamin B12 a day.

But some supplements available in stores contain up to 1000 micrograms of vitamin B12 and up to 100 milligrams of vitamin B6 – far more than the recommended dose.

Getty – Contributor

Researchers from Ohio State University analysed more than 77,000 patients aged between 50 and 70.

They were asked to report how much b-vitamins they consumed over the last 10 years, including dosage information from supplements.

Researchers took into accountpersonal smoking history, age, race, education, body size, alcohol consumption, personal history of cancer or chronic lung disease, family history of lung cancer and use of anti-inflammatory drugs before analysing if the vitamins put them at a greater risk of cancer.

Co-author Theodore Brasky said: “This sets all of these other influencing factors as equal, so we are left with a less confounded effect of long-term B6 and B12 super-supplementation.

“Our data shows that taking high doses of B6 and B12 over a very long period of time could contribute to lung cancer incidence rates in male smokers.

“This is certainly a concern worthy of further evaluation.”

Men who smoked and took more than 20 milligrams of vitamin B6 per day for 10 years were three times more likely to develop lung cancer.

Getty – Contributor

And men who smoked and took more than 55 micrograms of B12 per day for 10 years were four times more likely to develop the disease.

The risk was associated with taking more than 20 milligrams of vitamin B6 or 55 micrograms of B12 per day for 10 years.

But there was no similar link found in women.

The findings were published in the Journal of Clinical Oncology.

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High doses of energy-boosting vitamin B12 and B6 supplements … – The Sun

OncoBreak: Bad News via Microscope; Risky B Vitamins; End of … – MedPage Today

A patient who received anti-CD19 CAR T-cell therapy for relapsed/refractory lymphoma showed re-expansion of the genetically modified T-cells months after the initial infusion. (New England Journal of Medicine)

American Society of Clinical Oncology president Bruce Johnson, MD, discussed the impact on his career of learning that his aunt had breast cancer when he saw the cancer cells under a microscope as a trainee.

Final results of a randomized trial showed that patients with relapsed or refractory multiple myeloma lived significantly longer if the received carfilzomib (Kyprolis) plus dexamethasone instead of bortezomib (Velcade) and dexamethasone. (The Lancet Oncology)

Laboratory studies provided new insights into healthy skin cells’ ability to resist the effects of adjacent cells harboring cancer-causing mutations. (Fred Hutchinson Cancer Research Center)

Save the date: The third Tuesday in September is Take a Loved One for a Checkup Day. (American Cancer Society)

Preoperative radiation therapy led to complete surgical resection of soft-tissue sarcoma more often than receiving radiation after surgery. (University of California Davis)

Long-term use of vitamin B6 and B12 supplements had a significant association with an increased risk of lung cancer, particularly among men who smoked. (Ohio State University)

Florida residents seeking access to medical marijuana face long waits, as the number of applicants doubled in the past year to more than 31,000. (Miami Herald)

Discovery of a key metabolic pathway associated with recurrent endometrial cancer and treatment resistance might inform research to find new therapies for patients who currently have few options. (Cleveland Clinic)

Could a 20-year favorable trend toward diagnosis of small, early-stage kidney cancers be nearing an end? (University of California Davis)

2017-08-24T13:30:00-0400

Continued here:
OncoBreak: Bad News via Microscope; Risky B Vitamins; End of … – MedPage Today

Do Common Vitamins Raise Lung Cancer Risk? – WebMD

By Randy Dotinga

HealthDay Reporter

TUESDAY, Aug. 22, 2017 (HealthDay News) — Men, and especially male smokers, appear to be more likely to develop lung cancer if they take high doses of vitamins B6 and B12, new research suggests.

For men taking these vitamin supplements, the risk of lung cancer was nearly doubled. For men who smoked, the risk was between three and four times higher, the study found.

“High-dose B6 and B12 supplements should not be taken for lung cancer prevention, especially in men, and they may cause harm in male smokers,” said study lead author Theodore Brasky. He is a research assistant professor at Ohio State University.

However, the study wasn’t designed to prove cause-and-effect between the vitamins and lung cancer; it only showed an association.

It’s also not clear why only men and current male smokers seem to face an extra risk.

And a trade organization representing the vitamin industry cautioned against reading too much into the study.

Most people in the United States get enough vitamin B6 through their diets, according to the U.S. National Institutes of Health (NIH). Some people with certain health conditions may need supplements.

As for vitamin B12, the NIH reports that most Americans get enough from their diet. But some groups — such as older people and vegetarians — may be deficient and need supplements. The vitamin may also cause interactions with medications.

Dietary sources of vitamin B6 and B12 include fortified cereals and foods that are high in protein.

The new study included more than 77,000 adults, aged 50 to 76, in Washington state. The participants were recruited from 2000 to 2002, and answered questions about their vitamin use over the previous 10 years.

The researchers found that just over 800 of the study volunteers developed lung cancer over an average follow-up of six years.

The study found no sign of a link between folate (a type of B vitamin) and lung cancer risk. And vitamin B6 and B12 supplements didn’t seem to affect risk in women.

However, “we found that men who took more than 20 milligrams per day of B6 averaged over 10 years had an 82 percent increased risk of lung cancer relative to men who did not take supplemental B vitamins from any source,” Brasky said.

“Men who took more than 55 micrograms per day of B12 had a 98 percent increased lung cancer risk relative to men who did not take B vitamins,” he noted.

Men who smoked at the beginning of the study period and consumed high levels of the B vitamins were three to four times more likely to develop lung cancer, he added.

“B6 is typically sold in 100 mg (milligram)tablets. B12 is often sold between 500 mcg (microgram) and 3,000 mcg tablets,” Brasky said.

“In contrast, most multivitamins include 100 percent of the U.S. Recommended Dietary Allowance, which is under 2 mg per day for B6 and 2.4 mcg per day for B12. People should really ask themselves if they need over 1,200 times the RDA (recommended daily allowance) of a substance. There’s simply no scientific backing for these doses,” he said.

The study doesn’t conclusively link higher doses of the vitamins to higher rates of lung cancer. If there is a connection, it’s not clear how the vitamins might influence the cancer risk, Brasky said, although it may have something to do with how the vitamins interact with male sex hormones.

Paul Brennan, head of the genetics section with the International Agency for Research on Cancer, said the study appears to be valid.

However, the findings conflict with his group’s recent research, published July 22 in the Journal of the National Cancer Institute, which didn’t find any links between high blood levels of vitamin B6 and lung cancer in people at large, or men specifically.

“If anything,” Brennan said, “we found a small protective effect that was more apparent among men.”

Still, Brennan added that “there is clearly no evidence that these vitamins have any substantial protective effect. Smokers taking these vitamins should quit smoking.”

Dr. Eric Bernicker, a thoracic oncologist with Houston Methodist Hospital, agreed with that advice and said the study points to a higher risk of lung cancer from higher doses.

“There’s a strong belief that vitamins would never harm you. As in much of nutrition, the story is more complicated than that,” Bernicker said.

In a statement, Duffy MacKay, a senior vice president of the Council for Responsible Nutrition, a trade group for the vitamin industry, urged consumers “to resist the temptation to allow sensational headlines from this new study to alter their use of B vitamins.”

According to MacKay, “The numerous benefits of B vitamins from food and dietary supplements — including supporting cognition, heart health and energy levels — are well-established.”

In addition, McKay said, the study has limitations. Among other things, it required participants to remember what they consumed over 10 years.

The study was published Aug. 22 in the Journal of Clinical Oncology.

WebMD News from HealthDay

SOURCES: Theodore Brasky, Ph.D., research assistant professor, Ohio State University, Columbus, Ohio; Eric Bernicker, M.D., thoracic oncologist, Houston Methodist Hospital; Paul Brennan, Ph.D., head, genetics section, International Agency for Research on Cancer; Duffy MacKay, N.D., senior vice president, Council for Responsible Nutrition, Washington, D.C.; Aug. 22, 2017, Journal of Clinical Oncology

Continued here:
Do Common Vitamins Raise Lung Cancer Risk? – WebMD

Vitamin B6 and B12 Supplements Appear to Cause Cancer in Men – The Atlantic

Energy. If youre not taking vitamin B12, forget about having energy. As The Dr. Oz Show has recommended, End your energy crisis with Vitamin B12. The nice thing about sublingual pills is you dont need a doctor, you dont need a prescription.

And dont get me started on metabolism. If you want to supercharge your metabolism and energy levels, Amazon can deliver you a tall bottle of B12 supplements by the end of the day. Your metabolic processes will be the envy of the neighborhood. (Is Janice … on something? YesB12!)

These are the sort of vague marketing claims that have propelled the cobalt-based compounds sold as B12 into American hearts and minds and blood in ever-growing quantities. They are extrapolations from the fact that B12 deficiency causes anemia, and correcting that deficiency will alleviate symptoms of fatigue and weakness. But as the National Institutes of Health notes, Vitamin B12 supplementation appears to have no beneficial effect on performance in the absence of a nutritional deficit.

Nonetheless around 50 percent of people in the United States take some form of dietary supplement product, and among the most common are B vitamins. Worse than just a harmless waste of money, this usage could be actively dangerous. In an issue of the Journal of Clinical Oncology, published this week, researchers reported that taking vitamin B6 and B12 supplements in high doses (like those sold in many stores) appears to triple or almost quadruple some peoples risk of lung cancer.

This is a heavy claim about a very common substance, so its worth spending a minute on the methodology. Concerns about B-vitamin supplements and cancer have been percolating for years. They came up quietly in a large trial in Norway that concluded ten years ago. Starting in 1998, researchers assigned 6,837 people with heart disease to take either B vitamins or a placebo.

The researchers then watched as people died and contracted diseases in ensuing yearsand the vitamin group raised concerns. In 2009, the researchers reported in the Journal of the American Medical Association that taking high doses of vitamin B12 along with folic acid (technically vitamin B9) was associated with greater risk of cancer and all-cause mortality.

The largest increase in cancer risk was in the lung. Still, the number of cases of lung cancer among these 6,837 Norwegians was relatively smallso the actual risk was difficult to quantify. But it was big enough to catch the attention of Theodore Brasky and Emily White, two researchers at the Fred Hutchinson Cancer Research Center in Seattle. White had been overseeing a cohort study that involved more than ten times as many people as the Norwegian trial, some 77,000 people across the state of Washington. The cohort is tracking their supplement intake as we speak, and it is also being followed for cancers by the National Cancer Registry.

The Washington study was specifically designed to examine the roles of dietary supplementscompounds known as vitamins, minerals, and non-vitamin non-mineral compounds like ginsengin cancer risk. This was an ideal setup to look at the relationship between B vitamins and cancer, and see if it was indeed worthy of concern. So Brasky and White, along with Chi-Ling Chen at National Taiwan University, broke down this population by B-vitamin use and looked at cancers. Unfortunately their findings were even more significant than the Norwegian trial.

Lung-cancer risk among men who took 20 milligrams of B6 daily for years was twice that of men who didnt. Among people who smoke, the effect appeared to be synergistic, with B6 usage increasing risk threefold. The risk was even worse among smokers taking B12. Using more than 55 micrograms daily appeared to almost quadruple lung-cancer risk.

There was no apparent risk among womenwhich is not to say it doesnt exist, only that it wasnt apparent.

Why or how would B vitamins increase a persons risk of cancer?

I asked Brasky what he thought was going on. Its all hypothetical, and he has no clear idea bout the sex discrepancy. What he does know is that B vitamins all contribute enzymes and coenzymes to a metabolic pathway that breaks down folate in order to make the bases that comprise DNA. The pathway also regulates the expression of genes (by creating methyl groups that can essentially turn genes on and off). When we have too little of these B vitamins, this pathway can go wrong, leading to problems like incorporation of the wrong types of bases into DNA, which can cause breaks in the strands, and, in theory, lead to cancer.

Deficiency can also mean genes that should be inhibited are no longer inhibited, also potentially meaning cancer. Sufficiency of certain vitamins is important in cancer prevention, but avoiding excess appears to be similarly important.

Among smokers, who are already exposed to carcinogens, the effect of taking anything that impairs these cellular processes could be even more likely to lead to cancer.

The research team is quick to note that the doses of B vitamins in question are enormous. The U.S. Recommended Dietary Allowance for B6 is 1.7 milligrams per day, and for B12 its 2.4 micrograms. The high-risk group in the study was taking around 20 times these amounts.

That could seem nonsensical, except that these are the doses for sale at healthy-seeming places like Whole Foods and GNC. Many sellers offer daily 100-milligram B6 pills. B12 is available in doses of 5,000 micrograms.

I asked Brasky if his finding means that products like these should be more closely regulatedat least to require selling more reasonable doses, or to disclose risks, as is required for pharmaceuticals. Currently, supplements are absolved from this sort of requirement, or even to prove safety or efficacy before going to market. This is dictated by a 1994 law called the Dietary Supplement Health and Education Act (DSHEA).

The law was created by industry lobbying to keep the FDA away from regulation, so the industry self-regulates, said Brasky. But he deferred and said he hoped this article wouldnt be about regulation. I dont want to pick a fight with the vitamin industry for any reason.

So that falls to me. There are legitimate and important uses for B-vitamin supplements, but the emerging evidence suggests were best to treat them more like pharmaceuticals than like panaceas to be shoveled into us in pursuit of energy, metabolic fortitude, cardioprotection, bone wellness, or whatever way in which wed like to be better.

The enduring theme in health is that more doesnt mean better. Whats healthy for one person may be unhealthy for another. The fact of a product being sold without a prescription does not mean it is exempt, or that its good or even harmless. Any ingested bioactive substance will come with risks and benefits.

The current law gives consumers no reason to expect that risks will be listed on the labels of these products, or that health claims are accurate. A product like a high-dose B6 and B12 supplement hits shelves, and only decades later do researchers begin to understand the long-term health effects, who might benefit from taking it, and who might be harmed.

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Vitamin B6 and B12 Supplements Appear to Cause Cancer in Men – The Atlantic

Simplifying B-Complex Confusion: Why All 8 B Vitamins Are Beneficial – Newsmax

One question about B vitamins that may pop into your mind is: Why are there so many of them?

There are eight in all, says registered dietician Joan Salge Blake. When B vitamins were first discovered in the early 1900s, researchers thought there was only one. After more research, it became apparent that they were not a single substance but several different ones.

They are all water soluble and share many similarities. Together, they function to help the body convert carbohydrates, fats, and protein into glucose to burn for energy.

Even though they each have unique roles, the B vitamins perform a lot of the similar functions, says Joy Dubost, a registered dietician based in Washington, D.C. Its kind of a misnomer to think that B vitamins give you energy. Thats incorrect. What they do is help your food to give you energy.

Although B complex vitamins are vital to health, you typically dont hear much about them. One reason is because most Americans get an adequate amount through their diet, so theres no need to sound the alarm about great swaths of the population being deficient.

In general, for people to be deficient in the B vitamins, they have to be really malnourished, says Blake, a clinical associate professor at Boston University’s Sargent College of Health and Rehabilitation Sciences. Refined grains are enriched with thiamine, riboflavin, niacin and folic acid, and all of the Bs are in a wide variety of foods.

B vitamins are found in meat, poultry, seafood, eggs, dairy products, beans, leafy green vegetables, asparagus, avocado, nuts, seeds, and a host of fortified grains and cereals.

If you eat a well-balanced, healthy diet, you probably dont need a B-complex supplement, notes Dubost, former spokesperson for the Academy of Nutrition and Dietetics. The problem is that most people dont eat a well-balanced diet, so supplements are a good insurance policy. Since B vitamins are water-soluble, your body gets rid of the surplus through urine. Theres no risk of toxicity.

Here are some of the specific functions of the B vitamins:

B1 (Thiamine): Among other things, thiamine helps facilitate the transmission of nerve impulses, Blake tells Newsmax Health, adding, it also plays a role in breaking down alcohol in the body, so alcoholics need more of it.

B2 (Riboflavin): B2 is a potent antioxidant that helps fight damaging free radicals. It is also vital for red blood cell production. Due to its pigment, riboflavin turns urine bright yellow when excess is excreted.

B3 (Niacin): B3 dilates blood vessels, causing the niacin flush some people experience from taking supplements. When taken in very high doses, niacin can have a drug-like effect, says Blake. It can lower cholesterol levels, especially that of the bad LDL cholesterol. But it should only be taken in large doses under the care of a physician.

B5 (Pantothenic acid): Its name comes from the Greek word pantothen, meaning from everywhere. Thats because small amounts of B5 are found in so many foods. It helps the body produce stress and sex hormones, including testosterone.

B6 (Pyridoxine): B6 teams up with B9 and B12 to keep in check levels of the amino acid homocysteine, which can contribute to heart disease. It also helps to produce hormones that improve sleep and mood.

B7 (Biotin): Dubost tells Newsmax Health that women tend to gravitate towards biotin because its known as a hair, nail, and skin vitamin. But people are rarely deficient in it.

B9 (Folic acid): This vitamin is especially crucial for women. All women who are capable of becoming pregnant should make sure they get 400 micrograms of folic acid daily, Blake says. If they become pregnant, it can reduce the risk of birth defects.

B12: (Cobalamin): Vegans can become deficient in B12 because it is primarily found in animal products. Blake notes that between 10 percent and 30 percent of people over the age of 50 can also face deficiency issues because they have trouble breaking down the B12 in food. They have a better time using a synthetic version, she says.

2017 NewsmaxHealth. All rights reserved.

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Simplifying B-Complex Confusion: Why All 8 B Vitamins Are Beneficial – Newsmax

Are your vitamins putting you at higher risk for lung cancer? – WSB Radio

The Latest on Tropical Storm Harvey (all times local): 10:15 Houston Mayor Sylvester Turner is defending his decision not to ask residents to evacuate before the heavy rain from Tropical Storm Harvey swamped roads and neighborhoods across the nation’s fourth-largest city. Turner says at a news conference Sunday that there was no way to pinpoint which neighborhoods would be worst hit. He says every neighborhood has received at least some flooding. He says, ‘If you think the situation right now is bad and you give an order to evacuate, you are creating a nightmare.’ Turner asked people to stay in their homes and not drive if at all possible. Houston Fire Chief Samuel Pena says authorities have made more than 250 vehicle rescues in the storm. ___ 10:05 Houston Mayor Sylvester Turner says emergency personnel have responded to more than 2,000 calls to 911 for rescues in the wake of Hurricane Harvey. He said priority was being given to life-threatening calls. Turner also said at a news conference Sunday that he has ordered the downtown George R. Brown Convention Center opened as a shelter as floodwaters inundated much of the city. Turner also urged people not to drive, as numerous streets and roadways in Houston, the nation’s fourth largest city, were flooded Sunday. The George R. Brown Convention Center has 1.8 million square feet of space. ___ 9:50 a.m. A Catholic priest has used a kayak to get from his home in southeast Houston to higher ground and hoped to say Mass for people stranded on the streets. Father David Bergeron says that he tried to buy some wine for Mass at a convenience store but couldn’t because sales are prohibited in Texas on Sunday before noon. Bergeron tells television station KTRK that: ‘this is how America was evangelized by canoe.’ He says that he is praying for people affected by Tropical Storm Harvey. ___ 9:40 a.m. Staff at a Houston television station broadcasting live coverage of Tropical Storm Harvey had to evacuate after water from nearby flood-prone Buffalo Bayou started to gush into the building. KHOU-TV tweeted images Sunday of water pushing through a front door and flooding the lobby. Other images showed sand bags placed against another door had failed to stop the water that was already ankle deep. Floodwaters around 6:30 a.m. Sunday began seeping into the first-floor studio of KHOU, which is the CBS affiliate in the nation’s fourth largest city. The anchors and news operations then moved to a second floor as live coverage of Harvey continued. Later tweets say the station was being evacuated due to flooding. The station last flooded in 2001 during Tropical Storm Allison. ___ 9:35 a.m. Harris County sheriff’s spokesman Jason Spencer says flooding throughout the county that includes Houston and the region is so widespread that it’s ‘difficult to pinpoint the worst area.’ He says authorities are prioritizing hundreds of phones calls for help to ensure life-and-death situations ‘are at the top of the list.’ ‘It’s heartbreaking,’ he says. Spencer says the department has high-water vehicles and airboats but ‘certainly not enough.’ He says officials are encouraged that rescue teams from the National Guard and state agencies have also been deployed. ___ 9:25 a.m. The head of the Federal Emergency Management Agency says Hurricane Harvey is a ‘landmark event’ and the federal agency will be in the areas worst affected ‘for years.’ Brock Long says nearly 5,000 people from the federal government are doing search and rescue missions, helping to restore power and supporting what he calls ‘mass care missions.’ Speaking Sunday on CNN’s ‘State of the Union,’ Long said: ‘We expect a huge mass care mission today, of people flocking to shelters, if they can get to shelters.’ ___ 9:15 a.m. Texas Gov. Greg Abbott says that boats and helicopters are being deployed to help with swift-water rescues in the Houston area and parts of East Texas also facing flooding in the wake of Hurricane Harvey. Abbott, appearing on ‘Fox News Sunday,’ said: ‘We’re measuring rain these days not in inches but in feet.’ He tells ABC’s ‘This Week’ that they ‘could not be more appreciative’ of what the federal government and President Trump have done to help as Hurricane Harvey hit Texas. Abbott said on CNN’s ‘State of the Nation’ he’s talked to Trump several times and the head of FEMA. He says, ‘We’ve made multiple requests and we’re getting absolutely everything we need.’ Abbott said Harris County, which includes Houston, will soon be included in a federal disaster declaration as a result of Harvey. ___ 8:25 a.m. President Donald Trump says he will be traveling to Texas ‘as soon as that trip can be made without causing disruption’ in the wake of Hurricane Harvey. Trump tweeted that the ‘focus must be life and safety.’ At least two people are dead and more than a dozen injured due to the storm that has battered the region, including the cities of Corpus Christi and Houston. Trump has been complimenting the response to the storm on his Twitter feed, commending ‘Great coordination between agencies at all levels of government.’ Trump adds that: ‘Many people are now saying that this is the worst storm/hurricane they have ever seen. Good news is that we have great talent on the ground.’ The storm could linger for days in the region and could unload as much as 40 inches of rain on cities including Houston. ___ 8:15 a.m. The U.S. Coast Guard says it’s received more than 300 requests for urban search and rescue in the Houston area. The Coast Guard has five helicopters working the emergency calls and is asking for additional helicopters from New Orleans to help. Officials are advising people in dire straits to get to the roofs of their homes and mark them somehow to be seen from the air. They’re suggesting people wave sheets or towels. ___ 7:45 a.m. Flooding in some parts of the county that includes the city of Houston is so bad that residents are being urged to seek refuge on their roofs. Harris County Flood Control District official Jeff Lindner says people inundated by rising waters shouldn’t crawl into attics of their homes but should get on top of them. He says rainfall of more than 4 inches per hour has sent water higher than in recent Houston floods side and are exceeding levels seen in Tropical Storm Allison in June 2001. Lindner says areas south of the city appear hard-hit and some flooding is reported in downtown Houston and in the Texas Medical Center, which was devastated in Allison. He calls Harvey ‘a different animal’ from Allison and a ‘historic situation.’ He says he’s most amazed that he’s getting reports ‘of water into second-story of apartments and homes.’ Considering Houston’s flat terrain, ‘it’s very rare to get that depth of water.’ ___ 6:20 a.m. Authorities say rescue attempts continue in Houston for those stranded inside flooded homes and submerged vehicles in the wake of Harvey. The Houston Chronicle reports that hundreds of calls have been fielded for water rescues as of early Sunday, including Houston police officials who evacuated two apartment complexes and rescued more than 50 children. Meanwhile, Harris County Sheriff Ed Gonzalez and Houston Mayor Sylvester Turner on Sunday continued urging residents via Twitter to ‘shelter in place’ and stay off rain-swollen roadways. Gonzalez actively used Twitter overnight to field assistance for those trapped inside water-soaked homes, attics and vehicles. Those appealing for assistance or being steered to help via Gonzalez’s Twitter feed included a person suffering ‘cardiac-arrest,’ and a woman who posted: ‘I have 2 children with me and the water is swallowing us up. Please send help.’ Gonzalez at one point appealed for calm and patience, saying officials were ‘trying to make it to everyone as best we can.’ Turner’s official Twitter account said ‘911 services at capacity. If u can shelter in place do so, a few inches in your home is not imminent danger. Only call if in imminent danger.’ ___ 4:03 a.m. The National Hurricane Center says Harvey continues to cause ‘catastrophic flooding in southeastern Texas.’ The hurricane center says in its 4 a.m. Sunday update that the tropical storm has maximum sustained winds of 45 mph (72.42 kph) and remains stationary about 45 miles (72.42 kilometers) northwest of Victoria, Texas. A storm surge warning and a tropical storm warning also are both in effect for Port O’Connor to Sargent. The hurricane center says a storm surge warning means there is a danger of life-threatening inundation from rising water moving inland from the coastline. The center says Harvey is likely to weaken to a tropical depression later Sunday. Harvey made landfall Friday night as a Category 4 hurricane. Meanwhile, the National Weather Service says a Flash Flood Emergency over west and central Harris County, where Houston is located, as well as for eastern Fort Bend and northern Brazoria counties remains in effect until 6:15 a.m. Sunday, calling it a ‘Particularly Dangerous Situation.’ ___ 2:11 a.m. Jersey Village, Texas, officials are recommending that people who live along the White Oak Bayou, about 17 miles northwest of Houston, consider whether they need to evacuate their homes. Jersey Village City Manager Austin Bleess says the city issued a notice to residents about 1:30 a.m. saying the bayou looked like it would be out of its banks before long. He says city officials worried that streets may soon become impassable and wanted those residents to have time to make arrangements. ‘Certainly if people can stay in their homes, they can do that,’ Bleess said. ‘It’s quite possible that the streets could get impassable so we wanted to get that recommendation out.’ Bleess says the city is in the process of opening a storm shelter at the Champion Forest Baptist Church, Jersey Village chapter. ___ 1:20 a.m. The National Hurricane Center says Harvey continues to weaken at a slow pace as it produces torrential rains across parts of Southeast Texas. In its early Sunday update, the hurricane center said the tropical storm has maximum sustained winds of 45 mph (72.42 kph) and it is practically stationary about 45 miles (72.42 kilometers) northwest of Victoria, Texas. The airport in Austin, about 165 miles (265.53 kilometers) west of Houston, reported sustained winds of 38 mph. The center says Harvey is likely to weaken to a tropical depression later Sunday. Harvey made landfall Friday night as a Category 4 hurricane. Meanwhile, the National Weather Service extended a Flash Flood Emergency over west and central Harris County, where Houston is located, as well as for eastern Fort Bend and northern Brazoria counties until 6:15 a.m. Sunday, calling it a ‘Particularly Dangerous Situation.’ ___ 12:30 a.m. At least two people have died as Tropical Storm Harvey continues to dump rain on Southeast Texas. The Harris County medical examiner’s office confirmed the death of one person late Saturday in Harris County, but the office did not identify the cause of death. Gary Norman, a spokesman for the Houston emergency operations center, says the woman appeared to have gotten out of her vehicle in high water. She was found by neighbors about 30 yards away from the vehicle. Norman says she was pronounced dead at the scene by a doctor who was in the area. Earlier Saturday, Aransas County Judge C.H. ‘Burt’ Mills Jr. said the storm left one person dead in the county. Harvey came ashore Friday night as a Category 4 hurricane, but has since been downgraded to a tropical storm.

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Are your vitamins putting you at higher risk for lung cancer? – WSB Radio